The biology of stem cell factor, a new hematopietic growth factor involved in stem cell regulation Article Report uri icon

Overview

MeSH Major

  • Anxiety
  • Depression
  • Thalassemia

abstract

  • Recently, a new hematopoietic growth factor, stem cell factor, the ligand for the c-kit-proto-oncogene, has been cloned. The gene for this factor or for its receptor are deleted in two well know series of mice mutants which display pleiotropic stem cell defects. Therefore, this factor supposedly plays an important role in stem cell biology. This paper reviews some of the elegant genetic work which led to the discovery of the factor and of its receptor, the biological effects that this factor exerts in the hematopoietic system in normal individuals and in patients with Diamond-Blackfan anemia and speculates on some of its potential clinical applications. © 1993 Springer-Verlag.

publication date

  • December 1993

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1007/BF02592286

PubMed ID

  • 7686057

Additional Document Info

start page

  • 70

end page

  • 77

volume

  • 23

number

  • 1-4