Characterization of neuroendocrine differentiation in human benign prostate and prostatic adenocarcinoma Academic Article Article uri icon

Overview

MeSH Major

  • Disease Models, Animal
  • Fragile X Syndrome
  • Mutation, Missense

abstract

  • This analysis demonstrates that a significant proportion of primary and metastatic prostatic adenocarcinomas contain a subpopulation of NE cells, the expression of which does not appear to be suppressed with androgen ablation and does not correlate with pathologic stage. Furthermore, NE cells coexpress PSA, suggesting a common precursor cell of origin. The elaboration of biogenic amines and neuropeptides suggests that NE cells dispersed in prostatic carcinoma may play a paracrine growth-regulatory role.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19930615)71:12<3952::AID-CNCR2820711226>3.0.CO;2-X

PubMed ID

  • 7685237

Additional Document Info

start page

  • 3952

end page

  • 65

volume

  • 71

number

  • 12