Detection of immunoglobulin gene rearrangement of B cell nonHodgkin's lymphomas and leukemias in fresh, unfixed and formalin-fixed, paraffin- embedded tissue by polymerase chain reaction Academic Article uri icon

Overview

MeSH Major

  • DNA, Neoplasm
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain
  • Genes, Immunoglobulin
  • Immunoglobulin Variable Region
  • Leukemia, B-Cell
  • Lymphoma, B-Cell

abstract

  • Our results suggest that the monoclonality of human neoplastic B cells can be efficiently evaluated by PCR equally well from fresh, unfixed and formalin-fixed, paraffin-embedded tissues. This technique should prove to be a powerful tool in clinical diagnosis and research as well as in the retrospective analysis of archival pathologic specimens.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8515660

Additional Document Info

start page

  • 746

end page

  • 57

volume

  • 68

number

  • 6