Measurement of hepatobiliary function and hepatic hemodynamics in portally hypertensive rats
Mitral Valve Insufficiency
Background: Portal hypertension induced by partial ligation of the portal vein (PPVL) is associated with cardiovascular changes including portal systemic shunting (PSS). Despite large diversion of portal blood, there are no reports on the effect of PPVL on hepatobiliary function. Here we report on the effect of PPVL on liver function. Methods: Male Lewis rats were divided into 3 groups: control (n=10), PPVL (n=10) and bile duct ligated (BDL) (n=4). Under anesthesia, PPVL was performed around a 21-gauge needle and BDL was by ligation of the common bile duct. Under ether anesthesia, 0.1 mCi99mTc-labelled Hepatoiodida® was injected via the penile vein and scintigraphy performed. The heart and liver were chosen as regions of interest and the mean transit times for the heart (MTTheart) and liver (MTTliver) were calculated. PSS was measured by direct intraportal injection of57Co-labelled microspheres. Results: Portal pressure was significantly elevated in the PPVL group (p<0.001 vs. control) and PSS was in evidence (24±15%, SD, p<0,001). The MTTheart and MTTliver for the control group (97±12 sec and 357±49 sec, respectively) were not significantly different than those for the PPVL group (150±50 sec and 410±48 sec, respectively). In the BDL group, the MTTheart and MTTliver were significantly different from control and PPVL. Conclusions: We conclude from our results that despite the presence of significant PSS, no change in hepatobiliary function in rats with prehepatic portal hypertension occurs. © 1992 Blackwell Scientific Publications Ltd.
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