Endothelin-1 and Endothelin Receptor mRNA Expression in Normal and Atherosclerotic Human Arteries Academic Article uri icon

Overview

MeSH Major

  • Arteries
  • Arteriosclerosis
  • Endothelins
  • Receptors, Endothelin

abstract

  • Endothelin-1 (ET-1) is a potent vasoconstrictor peptide implicated in a number of human diseases including atherosclerosis. ET-1 binds to two distinct G protein-coupled receptors, known as the ETA and ETB receptor subtypes. In this study, we have examined ET-1, ETA and ETB mRNA expression levels in human vascular cells cultured in vitro and in normal and atherosclerotic human arteries. The results indicate that (a) ET-1 mRNA is constitutively expressed by endothelial cells but not by smooth muscle cells, (b) endothelial cells express only ETB mRNA but smooth muscle cells co-express ETA and ETB mRNA, and (c) in comparison to normal aorta, ET-1 mRNA expression is elevated and endothelin receptor mRNA expression is repressed in atherosclerotic lesions.

publication date

  • March 31, 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1993.1327

PubMed ID

  • 8466485

Additional Document Info

start page

  • 1081

end page

  • 8

volume

  • 191

number

  • 3