Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45 Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD45
  • Receptors, Antigen, T-Cell
  • Signal Transduction
  • T-Lymphocytes

abstract

  • Surface expression of the CD45 tyrosine phosphatase is essential for the T cell antigen receptor (TCR) to couple optimally with its second messenger pathways. CD45 may be required to dephosphorylate a TCR-activated protein tyrosine kinase, which then transduces an activation signal from the TCR. A chimeric molecule that contained extracellular and transmembrane sequences from an allele of a major histocompatibility class I molecule and cytoplasmic sequences of CD45 restored TCR signaling in a CD45-deficient mutant T cell line. Thus, expression of the complex extracellular domain of CD45 is not required for the TCR to couple to its signaling machinery.

publication date

  • December 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8475387

Additional Document Info

start page

  • 544

end page

  • 6

volume

  • 260

number

  • 5107