Comparison of peripheral blood leukocyte kinetics after live Escherichia coli, endotoxin, or interleukin-1α administration: Studies using a novel interleukin-1 receptor antagonist Academic Article uri icon

Overview

MeSH Major

  • Endotoxins
  • Escherichia coli
  • Interleukin-1
  • Leukocytes
  • Lipopolysaccharides

abstract

  • These results suggest that administration of recombinant human IL-1 alpha can replicate some of the characteristic patterns of hematologic change associated with bacteremia and endotoxemia. However, an endogenous IL-1 response is not required for these changes to occur. Rather, the data suggest that other inflammatory mediators induced by endotoxemia or gram-negative bacteremia, such as tumor necrosis factor-alpha (TNF alpha), may be involved.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1242904

PubMed ID

  • 8328833

Additional Document Info

start page

  • 79

end page

  • 90

volume

  • 218

number

  • 1