Carboxyatractylate inhibits the potentiating effect of lipophylic cation TPP+ on uncoupling activity of fatty acid. Academic Article uri icon

Overview

MeSH

  • Animals
  • Atractyloside
  • Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
  • Fluorescent Dyes
  • In Vitro Techniques
  • Oligomycins
  • Palmitic Acid
  • Phenazines
  • Rats
  • Spectrometry, Fluorescence
  • Uncoupling Agents

MeSH Major

  • Mitochondria, Heart
  • Onium Compounds
  • Organophosphorus Compounds
  • Oxygen Consumption
  • Palmitic Acids

abstract

  • The effect of TPP+ on the fatty acid or FCCP-induced uncoupling in rat heart mitochondria was studied. It was found that (a) TPP+ increases the stimulation of oxygen consumption by palmitic acid or FCCP in the presence of oligomycin, (b) TPP+ greatly enhances the palmitic acid or FCCP-induced delta psi decrease. Both effects of TPP+ were strongly suppressed by carboxyatractylate in the case of palmitate but were not in the case of FCCP. The role of ATP/ADP-antiporter in the TPP+ and palmitic acid effects is discussed.

publication date

  • August 1993

has subject area

  • Animals
  • Atractyloside
  • Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
  • Fluorescent Dyes
  • In Vitro Techniques
  • Mitochondria, Heart
  • Oligomycins
  • Onium Compounds
  • Organophosphorus Compounds
  • Oxygen Consumption
  • Palmitic Acid
  • Palmitic Acids
  • Phenazines
  • Rats
  • Spectrometry, Fluorescence
  • Uncoupling Agents

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 8220260

Additional Document Info

start page

  • 1161

end page

  • 1167

volume

  • 30

number

  • 6