Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Antipsychotic Agents
  • Autoimmunity
  • Dopamine
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Interleukin-1
  • Male
  • Middle Aged
  • Receptors, Dopamine
  • Stress, Physiological
  • Synaptic Transmission

MeSH Major

  • Interleukin-2
  • Schizophrenia

abstract

  • Levels of CSF fluid interleukin-2, but not interleukin-1 alpha, were found to be higher in 10 neuroleptic-free schizophrenic patients than in 10 healthy subjects matched for sex and age. Because interleukin-2 increases dopaminergic neurotransmission and participates in autoimmunity and cell growth, the authors postulate that elevated levels of central interleukin-2 might contribute to the increased dopaminergic neurotransmission, autoimmune phenomena, and abnormal brain morphology described in some patients with schizophrenia.

publication date

  • September 1993

has subject area

  • Adult
  • Aged
  • Antipsychotic Agents
  • Autoimmunity
  • Dopamine
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Interleukin-1
  • Interleukin-2
  • Male
  • Middle Aged
  • Receptors, Dopamine
  • Schizophrenia
  • Stress, Physiological
  • Synaptic Transmission

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 8102512

Additional Document Info

start page

  • 1408

end page

  • 1410

volume

  • 150

number

  • 9