Antibody-catalyzed degradation of cocaine Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Catalytic
  • Antibodies, Monoclonal
  • Cocaine

abstract

  • Immunization with a phosphonate monoester transition-state analog of cocaine provided monoclonal antibodies capable of catalyzing the hydrolysis of the cocaine benzoyl ester group. An assay for the degradation of radiolabeled cocaine identified active enzymes. Benzoyl esterolysis yields ecgonine methyl ester and benzoic acid, fragments devoid of cocaine's stimulant activity. Passive immunization with such an artificial enzyme could provide a treatment for dependence by blunting reinforcement.

publication date

  • March 26, 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8456315

Additional Document Info

start page

  • 1899

end page

  • 901

volume

  • 259

number

  • 5103