Treatment of experimental visceral leishmaniasis in a T-cell-deficient host: Response to amphotericin B and pentamidine Academic Article uri icon

Overview

MeSH Major

  • Amphotericin B
  • Immunocompromised Host
  • Leishmania donovani
  • Leishmaniasis, Visceral
  • Pentamidine
  • T-Lymphocytes

abstract

  • In experimental visceral leishmaniasis, euthymic but not athymic (nude) BALB/c mice respond to conventional treatment with pentavalent antimony, indicating that the in vivo efficacy of antimony is T cell dependent. This finding correlates with frequent antimony treatment failures for T-cell-deficient patients with visceral leishmaniasis. To determine whether the in vivo efficacies of alternative antileishmanial agents also require T cells, Leishmania donovani-infected euthymic and nude BALB/c mice were treated with pentamidine or amphotericin B. Pentamidine induced leishmanistatic activity in euthymic mice but had little effect in nude mice. In contrast, amphotericin B exerted potent leishmanicidal activities in both euthymic and nude animals. These results suggest that amphotericin B may be of particular use for T-cell-deficient patients with visceral leishmaniasis.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC188002

PubMed ID

  • 8363382

Additional Document Info

start page

  • 1504

end page

  • 5

volume

  • 37

number

  • 7