Quantitation of total metastatic tumor volume in the rat liver: correlation of MR and histologic measurements. Academic Article Article uri icon

Overview

MeSH

  • Animals
  • Neoplasm Transplantation
  • Rats

MeSH Major

  • Adenocarcinoma
  • Liver Neoplasms
  • Magnetic Resonance Imaging

abstract

  • Assessing tumor response to chemotherapy in the liver has always been difficult. Most investigators estimate tumor volume as either a product of the two perpendicular diameters of a tumor nodule, or, in animal studies, simply count surface tumor nodules. The authors evaluated magnetic resonance (MR) imaging as a technique for determining absolute tumor volume in the liver in an animal model. Specifically, histologic volumetric and MR imaging measurements of tumor and liver volumes were quantitatively compared over a wide range of tumor burdens in a rat model of hepatic metastasis of a colorectal carcinoma. Twenty-three rats were imaged, with two different section thicknesses used in each animal. Both section thicknesses showed highly significant correlations between MR and histologic measurements for both tumor and liver volumes (P less than .001). MR imaging may be useful for noninvasively quantifying tumor burden and temporal response of metastatic disease in the liver to novel antineoplastic regimens.

publication date

  • June 1992
  • May 1992

has subject area

  • Adenocarcinoma
  • Animals
  • Liver Neoplasms
  • Magnetic Resonance Imaging
  • Neoplasm Transplantation
  • Rats

Research

keywords

  • Comparative Study
  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 1627869

Additional Document Info

start page

  • 335

end page

  • 340

volume

  • 2

number

  • 3