Update on thalassemia. Review uri icon

Overview

MeSH Major

  • Thalassemia

abstract

  • Many advances in the understanding and management of the thalassemia syndromes have been made during the past several years. Our knowledge of normal globin gene function and of the consequences of specific mutations has been advanced by identification of the genetic defects causing thalassemia. Prenatal diagnosis is now possible with molecular biology technology. Standards have been established for transfusion, splenectomy, prevention of postsplenectomy infection, and effective iron chelation therapy. Bone marrow transplantation is now available for those with a compatible familial donor. Research efforts currently are directed toward safer blood products, oral iron chelators, and improved understanding of the developmental regulation of globin gene expression for effective gene transfer.

publication date

  • February 1992

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 1546001

Additional Document Info

start page

  • 55

end page

  • 62

volume

  • 13

number

  • 2