Experimental conduction block induced by serum from a patient with anti-GM1 antibodies Academic Article uri icon

Overview

MeSH Major

  • Antibodies
  • Blood Physiological Phenomena
  • G(M1) Ganglioside
  • Neural Conduction

abstract

  • Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti-GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum-induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5% of the fibers. After preabsorption with GM1, the serum had no effect, suggesting that the anti-GM1 antibodies were responsible for the conduction abnormalities.

publication date

  • April 1992

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1586139

Additional Document Info

start page

  • 385

end page

  • 90

volume

  • 31

number

  • 4