Collagenous enterocolitis: A manifestation of gluten-sensitive enteropathy Academic Article uri icon


MeSH Major

  • Celiac Disease
  • Collagen
  • Duodenitis
  • Enterocolitis
  • Glutens
  • Jejunal Diseases


  • We report coexistent collagenous colitis and collagenous sprue in a 62-year-old woman with diarrhea. Investigations suggested malabsorption, and small intestinal biopsies demonstrated a flattened mucosa with subepithelial collagen deposition. Colonic biopsies also showed a thickened subepithelial collagen band as well as a striking lamina propria inflammatory cell infiltrate. Symptomatic remission was induced with a gluten/lactose-free diet, oral prednisone, and sulfasalazine and has been maintained with gluten restriction alone. Repeat biopsies after 2 months demonstrated restoration of normal small intestinal and colonic collagen bands; only a chronic inflammatory cell infiltrate (consistent with microscopic/lymphocytic colitis) persisted in colonic biopsies. We propose that, in this instance, collagenous enterocolitis represented a diffuse manifestation of gluten sensitivity.

publication date

  • January 1992



  • Academic Article



  • eng

PubMed ID

  • 1500661

Additional Document Info

start page

  • 45

end page

  • 51


  • 15


  • 1