Chronic fluoxetine treatment reduces hypothalamic vasopressin secretion in vitro. Academic Article uri icon

Overview

MeSH

  • Animals
  • Desipramine
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Trazodone

MeSH Major

  • Arginine Vasopressin
  • Fluoxetine
  • Hypothalamus

abstract

  • Patients with obsessive-compulsive disorder (OCD) hypersecrete the arousal producing neurohormone arginine vasopressin (AVP) into the cerebrospinal fluid and plasma. Because OCD responds preferentially to potent serotonin uptake inhibitors, we compared the effect of chronic fluoxetine treatment to that of other antidepressants (trazodone and desipramine) on AVP release from rat hypothalamic organ culture and showed that only fluoxetine significantly reduced in vitro AVP release.

publication date

  • October 16, 1992

has subject area

  • Animals
  • Arginine Vasopressin
  • Desipramine
  • Fluoxetine
  • Hypothalamus
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Trazodone

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 1450938

Additional Document Info

start page

  • 311

end page

  • 313

volume

  • 593

number

  • 2