Fucoidan is a non-anticoagulant inhibitor of intimal hyperplasia Academic Article Article uri icon

Overview

MeSH Major

  • Fibrosarcoma
  • Magnetic Resonance Imaging
  • Neoplasm Recurrence, Local
  • Soft Tissue Neoplasms
  • Tomography, X-Ray Computed

abstract

  • We previously reported that heparin inhibits the proliferation of fibroblasts and vascular smooth muscle cells (SMC), in part, by binding to and increasing the antiproliferative activity of transforming growth factor-beta 1 (TGF-beta 1). We now report that certain other polyanions which are structurally distinct from heparin, such as fucoidan and polyinosinic acid, are more avid ligands for TGF-beta 1 and more potent antiproliferative agents than heparin. Fucoidan possessed more potent antiproliferative activity than heparin against rat and bovine aortic SMC in vitro, though possessing much lower anticoagulant activity than heparin. Furthermore, fucoidan suppressed in vivo intimal hyperplasia when continuously infused into rats subjected to balloon-catheter injury. Unlike heparin, which also suppressed intimal hyperplasia, fucoidan did not cause systemic anticoagulation. Thus, fucoidan may be useful as a non-anticoagulant inhibitor of post-angioplasty intimal hyperplasia.

publication date

  • April 30, 1992

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0006-291X(92)90657-7

PubMed ID

  • 1315533

Additional Document Info

start page

  • 773

end page

  • 81

volume

  • 184

number

  • 2