The relationship between thallium uptake, blood flow, and blood pool activity in bone and soft tissue tumors Academic Article Article uri icon


MeSH Major

  • Bone Neoplasms
  • Osteosarcoma


  • Twenty patients with known primary untreated and recurrent bone and soft tissue tumors underwent thallium imaging and three-phase bone imaging in the same session. The ratio of thallium uptake in the tumor tissue to the contralateral normal tissue areas was compared with the same ratio for phase 1 (blood flow or arterial phase), phase 2 (blood pool), and phase 3 (delayed medroxy-diphosphonate, MDP, uptake). There was poor correlation between Tl uptake and phases 1 and 3 of the bone scan ratios; r = 0.37 and 0.46; P = 0.097 and 0.047, respectively. The thallium uptake ratios correlated well with blood pool ratios (phase 2) (r = 0.84 and P less than 0.01). In contrast to uptake into normal muscle, Tl-201 uptake into tumor is not highly dependent on blood flow alone and other factors predominate in determining its magnitude.

publication date

  • July 20, 1992



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1097/00003072-199207000-00007

PubMed ID

  • 1638838

Additional Document Info

start page

  • 565

end page

  • 72


  • 17


  • 7