A combined small cell and spindle cell carcinoma of the lung: Report of a unique case with immunohistochemical and ultrastructural studies Academic Article Article uri icon


MeSH Major

  • Adenocarcinoma
  • Algorithms
  • Biomarkers, Tumor
  • Carcinoma, Squamous Cell
  • Immunohistochemistry
  • Lung Neoplasms


  • A unique bronchial tumor is reported. The tumor grew as an endobronchial polyp and obstructed the right main bronchus. Histologically the lesion consisted of two different types of neoplastic cells; epithelial small cell nests and atypical spindle-shaped cells. Immunohistochemical studies with a panel of antibodies showed that the small cell nests were immunoreactive for epithelial and neuroendocrine markers. The spindle-shaped cells showed positive staining for smooth muscle actin. Epithelial markers were also positive focally in the spindle cells. Electron microscopy confirmed that the spindle-shaped cells had both epithelial and mesenchymal features. Based on these results, the tumor was considered to be a unique combination of small cell and spindle cell carcinoma.

publication date

  • November 11, 1992



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1097/00000478-199211000-00010

PubMed ID

  • 1335211

Additional Document Info

start page

  • 1108

end page

  • 15


  • 16


  • 11