Acquired immunodeficiency without evidence of infection with human immunodeficiency virus types 1 and 2 Academic Article Article uri icon


MeSH Major

  • Gene Expression Regulation, Leukemic
  • Gene Expression Regulation, Viral
  • Herpesvirus 4, Human
  • Herpesvirus 8, Human
  • Lymphoma
  • NF-kappa B
  • Nitriles
  • Sulfones


  • There have been three published cases of acquired immunodeficiency in which no evidence for infection with human immunodeficiency virus (HIV) types 1 and 2 was found. We have identified five other individuals, from the New York City area (four who have known risk factors for HIV infection), with profound CD4 depletion and clinical syndromes consistent with definitions of the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. None had evidence of HIV-1, 2 infection, as judged by multiple serologies over several years, standard viral co-cultures for HIV p24 Gag antigen, and proviral DNA amplification by polymerase chain reaction.

publication date

  • August 1992



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0140-6736(92)92359-N

PubMed ID

  • 1353194

Additional Document Info

start page

  • 273

end page

  • 4


  • 340


  • 8814