Cognitive and motor impairments associated with SIV infection in rhesus monkeys Academic Article uri icon

Overview

MeSH Major

  • Cognition Disorders
  • Psychomotor Disorders
  • Simian Acquired Immunodeficiency Syndrome

abstract

  • Cognitive and motor deficits are now recognized as significant clinical features of infection with the human immunodeficiency virus (HIV). Juvenile rhesus macaques infected with simian immunodeficiency virus (SIV) were found to exhibit cognitive and motor deficits characteristic of HIV infection. Impairment on a motor skill task was the most reliable indicator of infection. Various cognitive impairments were also evident. These deficits were related to SIV infection of the brain but not to inflammatory lesions at a particular locus. The results suggest that the SIV-infected rhesus macaque is a valuable model for understanding the cause of HIV-associated central nervous system dysfunction and for developing a treatment.

publication date

  • March 6, 1992

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1546323

Additional Document Info

start page

  • 1246

end page

  • 9

volume

  • 255

number

  • 5049