Treatment of unresectable primary liver cancer with intrahepatic fluorodeoxyuridine and mitomycin C through an implantable pump Academic Article Article uri icon


MeSH Major

  • Acquired Immunodeficiency Syndrome


  • Ten patients with unresectable primary liver cancer, eight of whom had elevated serum alpha-fetoprotein levels, were treated with intrahepatic fluorodeoxyuridine (FUDR) and mitomycin C administered through an implantable pump. Four patients had a partial response, and two had a minor response. The median survival from initiation of treatment was 14.5 months (range, 2 to 32 months), with patients receiving therapy for a median of 11.2 months. In general, the therapy was well tolerated; only one patient had treatment-related biliary sclerosis. In conclusion, the combination of intrahepatic FUDR and mitomycin C was an effective palliative regimen for unresectable primary liver cancer, even in the presence of elevated serum alpha-fetoprotein levels. Further studies are needed to confirm these findings and compare this regimen with other methods of treatment for hepatocellular carcinoma.

publication date

  • January 1992



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19920215)69:4<920::AID-CNCR2820690414>3.0.CO;2-Y

PubMed ID

  • 1370918

Additional Document Info

start page

  • 920

end page

  • 4


  • 69


  • 4