Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma Academic Article uri icon

Overview

MeSH Major

  • Genes, p53
  • Mutation
  • Sarcoma

abstract

  • New germline mutations of the p53 gene are rare among patients with "sporadic" sarcoma but may be common in patients with sarcoma whose background includes either multiple primary cancers or a family history of cancer. Diverse mutations of this gene were associated with an increased likelihood of cancer; hence, the entire gene should be considered a target for heritable mutation. It appears that the group of patients with cancer who carry germline mutations of the p53 gene is more diverse than is suggested by the clinical definition of the Li-Fraumeni syndrome. The identification of carriers could be of substantial clinical importance.

publication date

  • January 1992

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1565143

Additional Document Info

start page

  • 1301

end page

  • 8

volume

  • 326

number

  • 20