Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK Academic Article uri icon


MeSH Major

  • Genes, Regulator
  • Genes, ras
  • Protein Kinase C
  • Protein Kinases
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins p21(ras)
  • Receptors, Cell Surface


  • p21c-ras plays a critical role in mediating tyrosine kinase-stimulated cell growth and differentiation. However, the pathways through which p21c-ras propagates these signals remain unknown. We report that in PC12 cells, expression of a dominant inhibitory mutant of ras, c-Ha-ras(Asn-17), antagonizes growth factor- and phorbol ester-induced activation of the erk-encoded family of MAP kinases, the 85-92 kd RSKs, and the kinase(s) responsible for hyperphosphorylation of the proto-oncogene product Raf-1. In addition, we find that expression of the activated ras oncogene is sufficient to stimulate these events. These data indicate that ras mediates nerve growth factor receptor and protein kinase C modulation of MAP kinases, RSKs, and Raf-1.

publication date

  • December 1992



  • Academic Article



  • eng

PubMed ID

  • 1312393

Additional Document Info

start page

  • 1041

end page

  • 50


  • 68


  • 6