Use of cisplatin for elderly patients Academic Article Article uri icon


MeSH Major

  • Clinical Trials as Topic
  • Neoplasms
  • Patient Selection
  • Research Subjects


  • The ageing of the population has resulted in a greater emphasis on cancer treatment effects in elderly patients. This population has often had arbitrary dose modification of chemotherapy owing to fear of excessive side-effects. A review was undertaken to evaluate cisplatin toxicity in patients of 70 years of age or older. Thirty-four patients were evaluated. Their mean age was 72.8 years and 85.3% were women. Fourteen of 34 (41%) patients completed the planned therapy. Treatment was terminated because of disease progression (35%), renal toxicity (9%) and non-renal toxicity (15%). Our conclusion is that cisplatin can safely be administered to elderly patients. Arbitrary dose modification or elimination of cisplatin from a treatment programme on the grounds of patient age alone is not justified.

publication date

  • May 1992



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1093/ageing/21.3.202

PubMed ID

  • 1615783

Additional Document Info

start page

  • 202

end page

  • 4


  • 21


  • 3