Wegener granulomatosis: An analysis of 158 patients Academic Article uri icon

Overview

MeSH Major

  • Cyclophosphamide
  • Granulomatosis with Polyangiitis
  • Prednisone

abstract

  • The course of Wegener granulomatosis has been dramatically improved by daily treatment with cyclophosphamide and glucocorticoids. Nonetheless, disease- and treatment-related morbidity is often profound. Alternative forms of therapy have not yet achieved the high rates of remission induction and successful maintenance that have been reported with daily cyclophosphamide treatment. Despite continued therapeutic success with cyclophosphamide, our long-term follow-up of patients with Wegener granulomatosis has led to increasing concerns about toxicity resulting from prolonged cyclophosphamide therapy and has encouraged investigation of other therapeutic regimens.

publication date

  • March 1992

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1739240

Additional Document Info

start page

  • 488

end page

  • 98

volume

  • 116

number

  • 6