The gp120 glycoprotein of HIV-1 binds to sulfatide and to the myelin associated glycoprotein Academic Article uri icon

Overview

MeSH Major

  • Glycolipids
  • HIV Envelope Protein gp120
  • HIV-1
  • Myelin Proteins
  • Proteoglycans
  • Sulfoglycosphingolipids

abstract

  • We investigated the binding of the gp120 glycoprotein of the human immunodeficiency virus (HIV-1) to neural glycolipids and glycoproteins by ELISA. The gp120 protein bound to sulfatide (GalS), a sulfated glycolipid autoantigen implicated in sensory neuritis, and to the myelin associated glycoprotein (MAG), an autoantigen in demyelinating neuropathy. Binding of gp120 to MAG was inhibited by the HNK-1 antibody, which recognizes a sulfated glucuronic acid epitope, suggesting that the interaction involves carbohydrate determinants. Sulfatide and MAG are potential receptors for gp120 in peripheral nerve and may have a role in the neuropathy associated with HIV-1 infection.

publication date

  • December 11, 1992

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/jnr.490330403

PubMed ID

  • 1282933

Additional Document Info

start page

  • 513

end page

  • 8

volume

  • 33

number

  • 4