Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: Transcriptional induction by γ-interferon is mediated through common DNA response elements Academic Article uri icon


MeSH Major

  • Antigens, Differentiation
  • Genes
  • Interferon-gamma
  • Promoter Regions, Genetic
  • Receptors, Fc
  • Transcription, Genetic


  • Expression of the high-affinity receptor for IgG (Fc gamma RI) is restricted to cells of myeloid lineage and is induced by gamma-interferon (IFN-gamma) but not by IFN-alpha/beta. The organization of the human Fc gamma RI gene has been determined and the DNA elements governing its cell type-restricted transcription and IFN-gamma induction are reported here. A 39-nucleotide sequence (IFN-gamma response region, or GRR) is defined that is both necessary and sufficient for IFN-gamma inducibility. Sequence analysis of the GRR reveals the presence of promoter elements initially defined for the major histocompatibility complex class II genes: i.e., X, H, and gamma-IRE sequences. Comparison of a number of genes whose expression is induced selectively by IFN-gamma indicates that the presence of these elements is a general feature of IFN-gamma-responsive genes. Our studies suggest that the combination of X, H, and gamma-IRE elements is a common motif in the pathway of transcriptional induction by this lymphokine.

publication date

  • December 1991



  • Academic Article



  • eng

PubMed Central ID

  • PMC53123

PubMed ID

  • 1837149

Additional Document Info

start page

  • 11305

end page

  • 9


  • 88


  • 24