The influence of local control on metastatic dissemination of prostate cancer treated by external beam megavoltage radiation therapy Academic Article Article uri icon


MeSH Major

  • Databases, Factual
  • Information Storage and Retrieval
  • Medicine
  • Natural Language Processing
  • Specialization
  • Vocabulary, Controlled


  • The influence of local control on metastatic dissemination was analyzed in 601 patients with clinically staged A2 to C prostate cancer treated by high-energy external beam radiation therapy who did not undergo hormonal manipulation before disease progression. Median follow-up for surviving patients was 7.7 years. Ninety-three patients had locally recurrent disease. The actuarial incidence of metastases in these patients (70% at 13 years) was significantly higher than in the 508 patients without local failure (40% at 13 years, P less than 0.001). High stage, high grade, prior transurethral resection, elevated acid phosphatase, disease fixation to the pelvic sidewall, and failure to perform a baseline bone scan correlated positively with the occurrence of metastases. However, except for a slight excess of Stage C, none of the metastatic predictors were more common in patients who failed locally than in those who did not. The Stage C preponderance does not account for the difference in incidence of metastases between the two groups, in as much as metastases were significantly more common in Stage C when disease recurred locally than when it did not. Thus, local control of prostate cancer does decrease the likelihood of metastatic disease. Moreover, patients with local control experienced a significantly better disease-specific survival than patients who failed locally.

publication date

  • January 1991



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19911201)68:11<2370::AID-CNCR2820681107>3.0.CO;2-T

PubMed ID

  • 1933773

Additional Document Info

start page

  • 2370

end page

  • 7


  • 68


  • 11