The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis. Academic Article uri icon

Overview

MeSH Major

  • Acetylcholine
  • Cystic Fibrosis
  • Potassium
  • Sweat Glands

abstract

  • Sweat glands isolated from skin obtained from normal subjects and patients with cystic fibrosis (CF) were pre-loaded with 86Rb+ and superfused with a physiological salt solution and the rate of 86Rb+ efflux was measured as an indicator of cellular potassium permeability. Acetylcholine always evoked a permeability increase in the glands from control subjects and this response could be resolved into calcium-dependent and calcium-independent components. Sweat glands from CF patients did not show such consistent responses. In three individuals the glands were abnormally insensitive to acetylcholine but normal responsiveness was seen in a fourth case. It is proposed that CF can induce dysfunction of calcium-dependent control processes in sweat glands.

publication date

  • July 1991

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1910765

Additional Document Info

start page

  • 573

end page

  • 8

volume

  • 76

number

  • 4