Role of candida in pathogenesis of antibiotic-associated diarrhoea in elderly inpatients Academic Article Article uri icon


MeSH Major

  • Anti-Bacterial Agents
  • Bacteria
  • Bacterial Infections
  • Cross Infection
  • Drug Resistance, Microbial
  • Long-Term Care


  • The part that candida plays in antibiotic-associated diarrhoea was investigated in 24 elderly inpatients (mean age 74 years) who tested negative for Clostridium difficile toxin and other intestinal pathogens. 7 had intestinal overgrowth of Candida species (greater than or equal to 10(5) cfu/ml). None of the 24 matched, antibiotic-treated controls without diarrhoea had candida overgrowth. All 5 patients with diarrhoea and candida overgrowth treated with oral nystatin responded with resolution of diarrhoea and lowering of faecal counts to less than 10(4) cfu/ml within 7 days of start of antifungal therapy despite continuation of antibacterial therapy. In the other 2 patients with candida overgrowth, the diarrhoea subsided spontaneously and faecal candida counts returned to normal (less than 10(4) cfu/ml) after antibacterial agents were withdrawn. In patients without candida overgrowth, diarrhoea persisted until antibiotics were withdrawn, at a mean of 16 days after study entry.

publication date

  • March 2, 1991



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0140-6736(91)91296-7

PubMed ID

  • 1671890

Additional Document Info

start page

  • 511

end page

  • 4


  • 337


  • 8740