Alpha 1-antitrypsin deficiency: pathogenesis and treatment. Review uri icon

Overview

MeSH

  • Alleles
  • Cholestasis
  • Deficiency Diseases
  • Exons
  • Female
  • Humans
  • Male
  • Neutrophils
  • Pancreatic Elastase
  • Phenotype
  • Pulmonary Emphysema
  • alpha 1-Antitrypsin

MeSH Major

  • alpha 1-Antitrypsin Deficiency

abstract

  • Inherited defects of the gene coding for a serum protein that protects alveolar walls from proteolysis constitute one cause of emphysema, with or without liver disease. The deficiency can be reversed with intravenous administration of the antiprotease, keeping serum levels above the minimum needed for lung protection.

publication date

  • February 15, 1991

has subject area

  • Alleles
  • Cholestasis
  • Deficiency Diseases
  • Exons
  • Female
  • Humans
  • Male
  • Neutrophils
  • Pancreatic Elastase
  • Phenotype
  • Pulmonary Emphysema
  • alpha 1-Antitrypsin
  • alpha 1-Antitrypsin Deficiency

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed ID

  • 1899256

Additional Document Info

start page

  • 81

end page

  • 4, 88-9, 93-4

volume

  • 26

number

  • 2