In vivo measurements of bone marrow cellularity using volume-localized proton NMR spectroscopy. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Biopsy
  • Female
  • Hematologic Diseases
  • Hematopoiesis
  • Hematopoietic Cell Growth Factors
  • Humans
  • Ilium
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Neoplasms

MeSH Major

  • Bone Marrow
  • Magnetic Resonance Imaging

abstract

  • Volume-localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24-h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P less than 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases.

publication date

  • May 1991

has subject area

  • Adult
  • Aged
  • Biopsy
  • Bone Marrow
  • Female
  • Hematologic Diseases
  • Hematopoiesis
  • Hematopoietic Cell Growth Factors
  • Humans
  • Ilium
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Neoplasms

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 2046540

Additional Document Info

start page

  • 85

end page

  • 95

volume

  • 19

number

  • 1