Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aerosols
  • Female
  • Humans
  • Macrophages
  • Male
  • Middle Aged
  • Pulmonary Alveoli
  • Superoxides

MeSH Major

  • Bronchoalveolar Lavage Fluid
  • Glutathione
  • Oxygen
  • Pulmonary Fibrosis

abstract

  • Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF.

publication date

  • July 27, 1991

has subject area

  • Adult
  • Aerosols
  • Bronchoalveolar Lavage Fluid
  • Female
  • Glutathione
  • Humans
  • Macrophages
  • Male
  • Middle Aged
  • Oxygen
  • Pulmonary Alveoli
  • Pulmonary Fibrosis
  • Superoxides

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 1676780

Additional Document Info

start page

  • 215

end page

  • 216

volume

  • 338

number

  • 8761