Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid) Academic Article uri icon

Overview

MeSH Major

  • Leukemia, Promyelocytic, Acute
  • Tretinoin

abstract

  • Tretinoin is a safe and highly effective agent for inducing complete remission in patients with acute promyelocytic leukemia. Clinical response to this agent is associated with leukemic-cell differentiation and is linked to the expression of an aberrant RAR-alpha nuclear receptor. Molecular detection of the aberrant receptor may serve as a useful marker for residual leukemia in patients with this disease.

publication date

  • May 16, 1991

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM199105163242002

PubMed ID

  • 1850498

Additional Document Info

start page

  • 1385

end page

  • 93

volume

  • 324

number

  • 20