Gamma interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: Antimicrobial role of limiting intracellular iron Article Comment uri icon

Overview

MeSH Major

  • Antiprotozoal Agents
  • Developing Countries
  • Disease Outbreaks
  • Interferon-gamma
  • Leishmaniasis
  • Leishmaniasis, Visceral

abstract

  • Iron-saturated transferrin did not reverse the intracellular killing or inhibition of Toxoplasma gondii, Chlamydia psittaci, or Leishmania donovani by gamma interferon-activated human macrophages. Deferoxamine, an iron chelator, also did not impair replication within unstimulated macrophages. Limiting the availability of intracellular iron is an unlikely mechanism in human macrophage activity against these three diverse pathogens.

publication date

  • December 13, 1991

Research

keywords

  • Comment

Identity

PubMed ID

  • 1937829

Additional Document Info

start page

  • 4684

end page

  • 6

volume

  • 59

number

  • 12