A randomized controlled trial of low-dose prednisone and ciclosporin versus high-dose prednisone in nephrotic syndrome of children Academic Article uri icon

Overview

MeSH Major

  • Cyclosporine
  • Nephrotic Syndrome
  • Prednisone

abstract

  • Twenty-eight patients with an onset of nephrotic syndrome within 1 year were randomized to receive either ciclosporin and low-dose prednisone or high-dose prednisone alone. Both groups were treated for 8 weeks. Thirteen of 14 children receiving combined therapy underwent remission versus only 8 of 14 children receiving prednisone alone (p less than 0.05). However, there was no difference between the two groups as regards the duration of remission after discontinuation of therapy. In patients receiving combined therapy, immunological studies showed that high interleukin producers had a more sustained remission. There was no evidence of ciclosporin-induced nephrotoxicity in this short-term therapeutic trial.

publication date

  • January 1991

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1944755

Additional Document Info

start page

  • 96

end page

  • 9

volume

  • 59

number

  • 1