Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation Academic Article uri icon


MeSH Major

  • Epilepsy
  • Hippocampus
  • Mutation
  • Neurons


  • A mutation at the tottering locus (tg, recessive, on chromosome 8) stimulates noradrenergic locus coeruleus axon terminal outgrowth and predisposes the brain to generalized spike-wave epilepsy in the young mouse. In an isolated synaptic circuit studied in vitro, the hyperinnervated mutant hippocampal pyramidal neurons respond normally when individually activated; however, latent neuronal signaling defects emerge during synchronous network bursting, revealing two conditional excitability phenotypes: a voltage-dependent prolongation of a complex synaptic response, the paroxysmal depolarizing shift, and a beta-adrenoreceptor-linked attenuation of the afterhyperpolarization. In this target brain region, the tg locus transforms neuronal excitability without altering measured intrinsic membrane properties, indicating that gene control of inherited epileptic traits may be mediated in part by activity-dependent modulation of network behavior favoring synchronous neuronal firing.

publication date

  • June 1991



  • Academic Article



  • eng

PubMed Central ID

  • PMC51741

PubMed ID

  • 2052555

Additional Document Info

start page

  • 4736

end page

  • 40


  • 88


  • 11