Efficient incorporation of human CD4 protein into avion leukosis virus particles Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD4
  • Avian Leukosis Virus
  • Viral Envelope Proteins

abstract

  • Virus envelope (Env) proteins are thought to contain specific signals for selective uptake by virus particles. In the course of attempting to define these signals by testing virus incorporation of CD4-Env chimeric proteins, normal human CD4 was found to be efficiently and selectively assembled into avian leukosis virus particles in quail cells. Viruses bearing CD4 at their surface may be useful reagents in the design of retrovirus-mediated gene therapy for the acquired immune deficiency syndrome.

publication date

  • December 7, 1990

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2175047

Additional Document Info

start page

  • 1421

end page

  • 3

volume

  • 250

number

  • 4986