Heavy chain variable region gene utilization in human antibodies Academic Article Article uri icon

Overview

MeSH Major

  • Anti-Inflammatory Agents
  • Cytokines
  • Inflammation
  • Interleukins
  • T-Lymphocytes, Regulatory

abstract

  • We have sequenced by the polymerase chain reaction the heavy chain variable regions of over thirty human antibodies of defined specificity. The distribution of VH families in this group of antibodies is disproportionately skewed toward the recently discovered VH gene families. Within a family, there is also a disproportional use of individual gene segments. Numerous explanations for these imbalances are discussed.

publication date

  • January 1990

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.3109/08830189009056731

PubMed ID

  • 2130119

Additional Document Info

start page

  • 231

end page

  • 8

volume

  • 5

number

  • 3-4