Dissociation of gp120 from HIV-1 virions induced by soluble CD4 Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD4
  • HIV Envelope Protein gp120
  • HIV-1
  • Virion

abstract

  • The CD4 antigen is the high affinity cellular receptor for the human immunodeficiency virus type-1 (HIV-1). Binding of recombinant soluble CD4 (sCD4) or the purified V1 domain of sCD4 to the surface glycoprotein gp120 on virions resulted in rapid dissociation of gp120 from its complex with the transmembrane glycoprotein gp41. This may represent the initial stage in virus-cell and cell-cell fusion. Shedding of gp120 from virions induced by sCD4 may also contribute to the mechanism by which these soluble receptor molecules neutralize HIV-1.

publication date

  • November 23, 1990

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2251501

Additional Document Info

start page

  • 1139

end page

  • 42

volume

  • 250

number

  • 4984