Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Academic Article Article uri icon

Overview

MeSH

  • Animals
  • Base Sequence
  • Blotting, Southern
  • Exons
  • Genome, Human
  • Humans
  • Immunoglobulin G
  • Introns
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Receptors, IgG
  • Recombination, Genetic
  • Restriction Mapping
  • Spleen

MeSH Major

  • Antigens, Differentiation
  • Multigene Family
  • Receptors, Fc

abstract

  • Receptors for immunoglobulin G immune complexes (Fc gamma RII and Fc gamma RIII) are expressed on most hematopoietic cells and show much structural and functional diversity. In order to determine the genetic basis for this diversity, a family of genes encoding the human and mouse receptors was isolated and characterized. Humans have five distinct genes for low-affinity Fc gamma Rs, in contrast to two in the mouse. With the use of yeast artificial chromosomes, the genes encoding the human receptors were oriented and linked, which established the structure of this complex locus. Comparison of the human and mouse genes generated a model for the evolutionary amplification of this locus.

publication date

  • May 11, 1990

has subject area

  • Animals
  • Antigens, Differentiation
  • Base Sequence
  • Blotting, Southern
  • Exons
  • Genome, Human
  • Humans
  • Immunoglobulin G
  • Introns
  • Mice
  • Molecular Sequence Data
  • Multigene Family
  • Mutation
  • Receptors, Fc
  • Receptors, IgG
  • Recombination, Genetic
  • Restriction Mapping
  • Spleen

Research

keywords

  • Comparative Study
  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 2139735

Additional Document Info

start page

  • 732

end page

  • 735

volume

  • 248

number

  • 4956