Distribution of trace levels of therapeutic gallium in bone as mapped by synchrotron x-ray microscopy. Academic Article uri icon

Overview

MeSH

  • Animals
  • Calcium
  • Female
  • Particle Accelerators
  • Rats
  • Rats, Inbred Strains
  • Spectrometry, X-Ray Emission

MeSH Major

  • Bone and Bones
  • Gallium

abstract

  • Gallium nitrate, a drug that inhibits calcium release from bone, has been proven a safe and effective treatment for the accelerated bone resorption associated with cancer. Though bone is a target organ for gallium, the kinetics, sites, and effects of gallium accumulation in bone are not known. We have used synchrotron x-ray microscopy to map the distribution of trace levels of gallium in bone. After short-term in vivo administration of gallium nitrate to rats, trace (nanogram) amounts of gallium preferentially localized to the metabolically active regions in the metaphysis as well as the endosteal and periosteal surfaces of diaphyseal bone, regions where new bone formation and modeling were occurring. The amounts measured were well below the levels known to be cytotoxic. Iron and zinc, trace elements normally found in bone, were decreased in amount after in vivo administration of gallium. These studies represent a first step toward understanding the mechanism(s) of action of gallium in bone by suggesting the possible cellular, structural, and elemental "targets" of gallium.

publication date

  • June 1990

has subject area

  • Animals
  • Bone and Bones
  • Calcium
  • Female
  • Gallium
  • Particle Accelerators
  • Rats
  • Rats, Inbred Strains
  • Spectrometry, X-Ray Emission

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC54065

PubMed ID

  • 2349224

Additional Document Info

start page

  • 4149

end page

  • 4153

volume

  • 87

number

  • 11