Shared actions of endotoxin and taxol on TNF receptors and TNF release Academic Article uri icon

Overview

MeSH Major

  • Alkaloids
  • Lipopolysaccharides
  • Macrophages
  • Receptors, Cell Surface
  • Tumor Necrosis Factor-alpha

abstract

  • Bacterial lipopolysaccharide (LPS) exerts profound effects on mammalian hosts in part by inducing macrophages to release tumor necrosis factor-alpha (TNF-alpha); the mechanisms involved are unresolved. The microtubule stabilizer taxol shared two actions of LPS on macrophages: it rapidly decreased TNF-alpha receptors and triggered TNF-alpha release. Both actions of taxol were absent in LPS-hyporesponsive C3H/HeJ mice. In recombinant inbred mice, the genes controlling responses to LPS and to taxol were closely linked. Dexamethasone blocked release of TNF-alpha by both stimuli but did not block the decrease in TNF-alpha receptors. Thus, a protein associated with microtubules may be a cellular target of LPS.

publication date

  • April 20, 1990

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1970196

Additional Document Info

start page

  • 370

end page

  • 2

volume

  • 248

number

  • 4953