B cell small lymphocytic lymphoma and chronic lymphocytic leukemia with peripheral neuropathy: Two cases with neuropathological findings and lymphocyte marker analysis Academic Article Article uri icon


MeSH Major

  • Antibodies, Anti-Idiotypic
  • Gangliosides
  • Immunoglobulin M
  • Myelin-Associated Glycoprotein


  • Two patients with lymphoproliferative disorders developed peripheral neuropathy and neoplastic lymphocytic nerve infiltrates. One of these patients, with B cell small lymphocytic lymphoma, presented with a chronic axonal neuropathy. CD22+, CD5- cells were identified in the epineurium. The other patient with chronic lymphocytic leukemia of 3 years duration developed a mixed axonal and demyelinating neuropathy. CD22+ and CD5+ cells were observed in the endoneurium. While the cause of the neuropathy in these two cases is unknown, intraneural or systemic autoantibody production may have led to the development of disease.

publication date

  • July 11, 1990



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/BF00308924

PubMed ID

  • 2167605

Additional Document Info

start page

  • 198

end page

  • 203


  • 80


  • 2