Epirubicin and ifosfamide in patients with refractory breast cancer and other metastatic solid tumours Academic Article Article uri icon


MeSH Major

  • Biomedical Research
  • Guidelines as Topic
  • Head and Neck Neoplasms
  • Lung Neoplasms
  • Smoking
  • Tobacco Use


  • The combination of ifosfamide (IFO) and epirubicin (EPI) has been found to be an effective regimen in the treatment of metastatic tumours and shows remarkable activity in heavily pretreated breast cancer patients. A combination of EPI (35 mg/m2 on days 1 and 2) and IFO (1.8-2.5 g/m2 on days 1-5) was given to 58 patients with refractory breast cancer (n = 23), metastatic sarcomas (n = 15) and other solid tumours (n = 20). Due to extensive prior therapy, the IFO dose had to be adapted to the individual haematological situation. In all, 55 patients were evaluable; we observed 5 complete (CRs) and 16 partial responses (PRs). In addition, 18 patients experienced a minor response (MR) or no change (NC). The median duration of all responses was 6.7 months. Toxicity was generally mild and closely related to previous therapy.

publication date

  • January 1990



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/BF00685425

PubMed ID

  • 2347053

Additional Document Info

start page

  • S69

end page

  • 70


  • 26


  • 1 Supplement