Characterization of HNK-1 bearing glycoproteins in human peripheral nerve myelin Academic Article uri icon

Overview

MeSH Major

  • Antigens, Differentiation
  • Cauda Equina
  • Glycoproteins
  • Myelin Proteins

abstract

  • The HNK-1 carbohydrate epitope, which is shared by several members of the immunoglobulin gene super-family, is also the target epitope for IgM anti-MAG autoantibodies in patients with demyelinating neuropathy. By Western blot analysis, there are 7 HNK-1 immunoreactive glycoproteins in human peripheral nerve myelin, two of which have previously been identified as the myelin associated glycoprotein (MAG) and the P0 glycoprotein. In this study, the remaining HNK-1 bearing glycoprotein bands were characterized by immunoblot and NH2-terminal sequence analysis, and were all identified as degradation products or aggregates of the Po glycoprotein. MAG and P0 are therefore the only HNK-1 bearing glycoproteins in human peripheral nerve myelin.

publication date

  • January 1990

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1691305

Additional Document Info

start page

  • 295

end page

  • 9

volume

  • 25

number

  • 3