Antibodies to a putative HIV gp41 immunosuppressive peptide, pHIVIS (583-599), do not correlate significantly with outcome in HIV infection Academic Article uri icon


MeSH Major

  • HIV Antibodies
  • HIV Envelope Protein gp41
  • HIV Infections
  • Peptide Fragments


  • We have studied the prevalence of antibodies to peptides derived from the transmembrane protein of HIV, gp41. Previous work has suggested that the presence of antibodies to the gp41 peptide known as pHIVIS (env 583-599) is associated with protection from immunosuppression in HIV infection. We studied 171 sequential sera from 55 HIV-1-infected people in various clinical stages of disease. There was no significant association between antibodies to pHIVIS and clinical status in this study. Although pHIVIS has sequence similarity to the putative immunosuppressive region of the C-type oncornaviruses (p15E), antibodies to this peptide do not appear to be associated with protection from immunosuppression in natural HIV infection.

publication date

  • January 1990



  • Academic Article



  • eng

PubMed ID

  • 2350445

Additional Document Info

start page

  • 251

end page

  • 3


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