Down-regulation of LFA-1 adhesion receptors by C-myc oncogene in human B lymphoblastoid cells Academic Article uri icon

Overview

MeSH Major

  • B-Lymphocytes
  • Lymphocyte Function-Associated Antigen-1
  • Proto-Oncogene Proteins c-myc
  • Proto-Oncogenes

abstract

  • The function of the c-myc gene and its role in tumorigenesis are poorly understood. In order to elucidate the role of c-myc oncogene activation in B cell malignancy, the phenotypic changes caused by the expression of c-myc oncogenes in human B lymphoblastoid cells immortalized by Epstein-Barr virus were analyzed. C-myc oncogenes caused the down-regulation of lymphocyte function-associated antigen-1 (LFA-1) adhesion molecules (alpha L/beta 2 integrin) and loss of homotypic B cell adhesion in vitro. Down-regulation of LFA-1 occurred by (i) posttranscriptional modulation of LFA-1 alpha L-chain RNA soon after acute c-myc induction, and (ii) transcriptional modulation in cells that chronically express c-myc oncogenes. Analogous reductions in LFA-1 expression were detectable in Burkitt lymphoma cells carrying activated c-myc oncogenes. Since LFA-1 is involved in B cell adhesion to cytotoxic T cells, natural killer cells, and vascular endothelium, these results imply functions for c-myc in normal B cell development and lymphomagenesis.

publication date

  • November 2, 1990

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2237417

Additional Document Info

start page

  • 682

end page

  • 6

volume

  • 250

number

  • 4981