Prostaglandin E2 enhances and gamma interferon inhibits germ tube formation in Candida albicans Academic Article uri icon

Overview

MeSH Major

  • Candida albicans
  • Dinoprostone
  • Interferon-gamma

abstract

  • Prostaglandin E2 (PGE2), an immunosuppressive monokine that increases intracellular cyclic AMP (cAMP) levels, stimulated Candida albicans germ tube formation. Dibutyryl cAMP (dB-cAMP) and isoproterenol, other compounds that increase cAMP levels, also stimulated germination. Gamma interferon (IFN-gamma), a product of cellular immune system activation, inhibited Candida germ tube formation, even in the presence of PGE2, dB-cAMP, and isoproterenol. Thus, PGE2 and IFN-gamma as well as having opposing roles in the suppression or activation of cell-mediated immunity, are also antagonists for the yeast-to-hyphal transition of C. albicans.

publication date

  • January 1990

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC258440

PubMed ID

  • 2152888

Additional Document Info

start page

  • 260

end page

  • 2

volume

  • 58

number

  • 1